Hematopathology

We offer comprehensive hematopathology services, including expert second opinion consultations and start-to-finish bone marrow procedures supervised by hematopathologists. We accept peripheral blood, bone marrow, lymph nodes, fresh tissue biopsies, body fluids, fine needle aspirates and formalin fixed paraffin embedded specimens for hematopathology testing.

Through our 20/20 Core Evaluation option, our board certified cancer experts can determine the medically necessary testing for your patient. By ordering the 20/20 Core Evaluation option, providers can expect to receive 1 concise pathology report that summarizes morphology, flow cytometry, fluorescence in situ hybridization (FISH), cytogenetics and molecular test results for a more streamlined hematopathology approach.

See below for more details on our hematopathology methodologies and test services:

20/20 Core Evaluation Report

Pathology Consultation with Morphologic Interpretation and/or Ancillary Studies (Flow Cytometry, Routine Chromosome Analysis, FISH, PCR and/or NGS); if clinically indicated.

Acute Leukemia Panel (Usually performed on bone marrow/peripheral blood. Acute leukemia panel includes lymphoma markers.)
Lymphoma Panel (Usually performed on tissue and fluid.)
CLL Prognostic Panel
Immunodeficiency Panel
PNH Panel
Myeloma Panel

Cytogenetics

Routine Chromosome Analysis
Specimen Culture and Hold

FISH Panels

ALL
AML
CLL
CML
Myeloma
MDS
Eosinophilia
High-Grade/Large B-Cell Lymphoma
B-Cell NHL Panel
Specimen Culture and Hold

FISH Probes

ALK/Lymphoma (2p23)
ATM (11q22)
BCL6 (3q27)
BCR-ABL1/ASS1 t(9;22)
CBFB/MYH11 inv(16)
CKS1B/CDKN2C (1p/1q)
ETV6/RUNX1 t(12;21)
FGFR1 (8p11)
IGH (14q32)
IGH/BCL2 t(14;18)
IGH/CCND1 t(11;14)
IGH/FGFR3 t(4;14)
IGH/MAF t(14;16)
IGH/MYC t(8;14)
MALT1 (18q21)
KMT2A (MLL; 11q23)
MYC (8q24)
PDGFRA (4q12)
PDGFRB (5q32)
PML/RARA t(15;17)
RUNX1T1/RUNX1 (ETO/AML1) t(8;21)
TP53 (17p13)
5q-/-5
6q21/6q23
7q-/-7
+8
+12
13q-/-13
20q-
POC Ploidy: FISH on Formalin Fixed Products of Conception, Common Trisomies and Triploidies, Chromosomes 13/16/18/21/X/Y

Next-Generation Sequencing

Hematology Profile (DNA) (177 genes)
Hematology Fusion Profile (RNA) (68 genes)
Hematology Profile Plus Fusion (DNA and RNA)
DNA Extraction and Hold

Molecular

JAK2 V617F Mutation
MPN Molecular Panel (JAK2 V617F, JAK2 exon 12-14, CALR, and MPL Mutation Analysis)
JAK2 exon 12-14 Mutation
CALR Mutation
MPL Mutation
BCR-ABL1 p210/p190 (PCR - Quantitative)
MYD88 L265P Mutation
FLT3 Mutation
FLT3/NPM1 Mutation
NPM1 Mutation
PML/RARA (PCR)
IDH1 and 2 Mutation
SF3B1 Mutation
B-cell Clonality
T-cell Clonality
IgVH Hypermutation
BRAF V600E Mutation
STAT3 Mutation
CEBPA Mutation
ABL1 Kinase Domain Mutation
ASXL1 Mutation
BTK Inhibitor Acquired Resistance Panel (BTK and PLC-gamma2)
BTK Mutation (C481S Mutation and Others)
CXCR4 Mutation
EZH2 Mutation
KIT D816V Mutation
KRAS/NRAS Mutation
MLL-PTD Mutation
SRSF2 Mutation
TET2 Mutation
U2AF1 Mutation
ZRSR2 Mutation